BDBM50330934 CHEMBL1277876::N-((2-Pyrrolidin-1-yl-pyridin-3-yl)methyl)-6-(4-chlorophenyl)-pyrazine-2-carboxamide

SMILES: Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCCC1

InChI Key: InChIKey=XUEHBVFEQMVDHJ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330934   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated sodium channel subunit alpha Nav1.8 (Rattus norvegicus (Rat))	BDBM50330934 (CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCCC1 Show InChI InChI=1S/C21H20ClN5O/c22-17-7-5-15(6-8-17)18-13-23-14-19(26-18)21(28)25-12-16-4-3-9-24-20(16)27-10-1-2-11-27/h3-9,13-14H,1-2,10-12H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of tetrodotoxin-resistant NaV1.8 in rat dorsal root ganglion neurons at holding potential -100 mV by whole-cell patch clamp electrophysiol...				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM50330934 (CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCCC1 Show InChI InChI=1S/C21H20ClN5O/c22-17-7-5-15(6-8-17)18-13-23-14-19(26-18)21(28)25-12-16-4-3-9-24-20(16)27-10-1-2-11-27/h3-9,13-14H,1-2,10-12H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltageclamp electrophysiology assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type X alpha subunit (Mus musculus)	BDBM50330934 (CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCCC1 Show InChI InChI=1S/C21H20ClN5O/c22-17-7-5-15(6-8-17)18-13-23-14-19(26-18)21(28)25-12-16-4-3-9-24-20(16)27-10-1-2-11-27/h3-9,13-14H,1-2,10-12H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NaV1.8 expressed in HEK293 cells by isotopic efflux assay				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50330934 (CHEMBL1277876 | N-((2-Pyrrolidin-1-yl-pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1cncc(n1)C(=O)NCc1cccnc1N1CCCC1 Show InChI InChI=1S/C21H20ClN5O/c22-17-7-5-15(6-8-17)18-13-23-14-19(26-18)21(28)25-12-16-4-3-9-24-20(16)27-10-1-2-11-27/h3-9,13-14H,1-2,10-12H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant NaV1.2 by electrophysiology				Bioorg Med Chem 18: 7816-25 (2010) Article DOI: 10.1016/j.bmc.2010.09.057 BindingDB Entry DOI: 10.7270/Q24B31KG
					More data for this Ligand-Target Pair