BDBM50331030 (Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one::CHEMBL1276981

SMILES: CCN(CC)CCN1CCCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O

InChI Key: InChIKey=DIWNHTDZEZGKJK-JXAWBTAJSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331030 ((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...) Show SMILES CCN(CC)CCN1CCCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C24H29FN4O2/c1-4-28(5-2)11-12-29-10-6-7-20-22(24(29)31)15(3)21(26-20)14-18-17-13-16(25)8-9-19(17)27-23(18)30/h8-9,13-14,26H,4-7,10-12H2,1-3H3,(H,27,30)/b18-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human VEGFR2 after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50331030 ((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...) Show SMILES CCN(CC)CCN1CCCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C24H29FN4O2/c1-4-28(5-2)11-12-29-10-6-7-20-22(24(29)31)15(3)21(26-20)14-18-17-13-16(25)8-9-19(17)27-23(18)30/h8-9,13-14,26H,4-7,10-12H2,1-3H3,(H,27,30)/b18-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of VEGFR2-induced cell proliferation in HUVEC after 72 hrs by sulforhodamine B method				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50331030 ((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...) Show SMILES CCN(CC)CCN1CCCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C24H29FN4O2/c1-4-28(5-2)11-12-29-10-6-7-20-22(24(29)31)15(3)21(26-20)14-18-17-13-16(25)8-9-19(17)27-23(18)30/h8-9,13-14,26H,4-7,10-12H2,1-3H3,(H,27,30)/b18-14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of c-Kit after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50331030 ((Z)-5-(2-Diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2...) Show SMILES CCN(CC)CCN1CCCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O Show InChI InChI=1S/C24H29FN4O2/c1-4-28(5-2)11-12-29-10-6-7-20-22(24(29)31)15(3)21(26-20)14-18-17-13-16(25)8-9-19(17)27-23(18)30/h8-9,13-14,26H,4-7,10-12H2,1-3H3,(H,27,30)/b18-14-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceuticals Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human PDGFRbeta after 30 mins by ELISA				J Med Chem 53: 8140-9 (2010) Article DOI: 10.1021/jm101036c BindingDB Entry DOI: 10.7270/Q2BV7GWF
					More data for this Ligand-Target Pair