BindingDB PrimarySearch

BDBM50331290 CHEMBL1289953::N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophen-2-ylmethyl)benzamide

SMILES: Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1

InChI Key: InChIKey=LCQJRANJHOEQFG-UHFFFAOYSA-N

Data: 9 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50331290
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Renovis, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...				Bioorg Med Chem Lett 20: 7076-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.099 BindingDB Entry DOI: 10.7270/Q2DN459H
Renovis, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Renovis, Inc. Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...				Bioorg Med Chem Lett 20: 7076-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.099 BindingDB Entry DOI: 10.7270/Q2DN459H
Renovis, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of TRPM8 (unknown origin)				J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	414	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium increase by Fluo-4 AM base...				Bioorg Med Chem 25: 727-742 (2017) Article DOI: 10.1016/j.bmc.2016.11.049 BindingDB Entry DOI: 10.7270/Q2445PF7
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...				J Med Chem 63: 9672-9694 (2020)
University of Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	589	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant full length TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase preinc...				Bioorg Med Chem 25: 727-742 (2017) Article DOI: 10.1016/j.bmc.2016.11.049 BindingDB Entry DOI: 10.7270/Q2445PF7
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...				Bioorg Med Chem 25: 727-742 (2017) Article DOI: 10.1016/j.bmc.2016.11.049 BindingDB Entry DOI: 10.7270/Q2445PF7
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d...				J Med Chem 61: 6140-6152 (2018) Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3
University of Salerno Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50331290 (CHEMBL1289953 \| N-(3-aminopropyl)-2-(3-methylbenzy...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	448	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium increase by Fluo-4 AM based...				Bioorg Med Chem 25: 727-742 (2017) Article DOI: 10.1016/j.bmc.2016.11.049 BindingDB Entry DOI: 10.7270/Q2445PF7
Kissei Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair