BDBM50331371 CHEMBL1290275::N-((3R,4R)-4-(4'-cyanobiphenyl-4-yl)-1-ethylpyrrolidin-3-yl)propane-2-sulfonamide

SMILES: CCN1C[C@H](NS(=O)(=O)C(C)C)[C@H](C1)c1ccc(cc1)-c1ccc(cc1)C#N

InChI Key: InChIKey=OXFGNMCLRIFXSJ-YADHBBJMSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331371   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50331371 (CHEMBL1290275 | N-((3R,4R)-4-(4'-cyanobiphenyl-4-y...) Show SMILES CCN1C[C@H](NS(=O)(=O)C(C)C)[C@H](C1)c1ccc(cc1)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C22H27N3O2S/c1-4-25-14-21(22(15-25)24-28(26,27)16(2)3)20-11-9-19(10-12-20)18-7-5-17(13-23)6-8-18/h5-12,16,21-22,24H,4,14-15H2,1-3H3/t21-,22+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human hERG				Bioorg Med Chem Lett 20: 7116-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.062 BindingDB Entry DOI: 10.7270/Q2WQ042G
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50331371 (CHEMBL1290275 | N-((3R,4R)-4-(4'-cyanobiphenyl-4-y...) Show SMILES CCN1C[C@H](NS(=O)(=O)C(C)C)[C@H](C1)c1ccc(cc1)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C22H27N3O2S/c1-4-25-14-21(22(15-25)24-28(26,27)16(2)3)20-11-9-19(10-12-20)18-7-5-17(13-23)6-8-18/h5-12,16,21-22,24H,4,14-15H2,1-3H3/t21-,22+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Positive modulation of human GluA2 flip receptor by FLIPR assay				Bioorg Med Chem Lett 20: 7116-9 (2010) Article DOI: 10.1016/j.bmcl.2010.09.062 BindingDB Entry DOI: 10.7270/Q2WQ042G
					More data for this Ligand-Target Pair