BDBM50331420 2,5-Dimethyl-oxazole-4-carboxylic acid {3-[(1,1-dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-propyl}-amide::CHEMBL1289964

SMILES: Cc1nc(C(=O)NCCCN(C2=NS(=O)(=O)c3ccccc23)c2ccccc2)c(C)o1

InChI Key: InChIKey=NQCDBLMPXRGTLC-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331420   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50331420 (2,5-Dimethyl-oxazole-4-carboxylic acid {3-[(1,1-di...) Show SMILES Cc1nc(C(=O)NCCCN(C2=NS(=O)(=O)c3ccccc23)c2ccccc2)c(C)o1 |t:11| Show InChI InChI=1S/C22H22N4O4S/c1-15-20(24-16(2)30-15)22(27)23-13-8-14-26(17-9-4-3-5-10-17)21-18-11-6-7-12-19(18)31(28,29)25-21/h3-7,9-12H,8,13-14H2,1-2H3,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay				Bioorg Med Chem Lett 20: 6983-8 (2010) Article DOI: 10.1016/j.bmcl.2010.09.132 BindingDB Entry DOI: 10.7270/Q2N58MMS
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