BDBM50331445 4-[(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-phenyl-amino]-N-(4-fluoro-phenyl)-butyramide::CHEMBL1289848

SMILES: Fc1ccc(NC(=O)CCCN(C2=NS(=O)(=O)c3ccccc23)c2ccccc2)cc1

InChI Key: InChIKey=WMRVXDMDVMZLLT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated potassium channel (Homo sapiens (Human))	BDBM50331445 (4-[(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-y...) Show SMILES Fc1ccc(NC(=O)CCCN(C2=NS(=O)(=O)c3ccccc23)c2ccccc2)cc1 |t:12| Show InChI InChI=1S/C23H20FN3O3S/c24-17-12-14-18(15-13-17)25-22(28)11-6-16-27(19-7-2-1-3-8-19)23-20-9-4-5-10-21(20)31(29,30)26-23/h1-5,7-10,12-15H,6,11,16H2,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay				Bioorg Med Chem Lett 20: 6983-8 (2010) Article DOI: 10.1016/j.bmcl.2010.09.132 BindingDB Entry DOI: 10.7270/Q2N58MMS
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