BDBM50331900 CHEMBL1289227::E-6-Chloro-3-[[4-(methylsulfonyl)phenyl]methylene]-indolin-2-one

SMILES: CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)cc1

InChI Key: InChIKey=SBWAYPHCJJARIX-RIYZIHGNSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331900   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Oryctolagus cuniculus)	BDBM50331900 (CHEMBL1289227 | E-6-Chloro-3-[[4-(methylsulfonyl)p...) Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)cc1 Show InChI InChI=1S/C16H12ClNO3S/c1-22(20,21)12-5-2-10(3-6-12)8-14-13-7-4-11(17)9-15(13)18-16(14)19/h2-9H,1H3,(H,18,19)/b14-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...				Bioorg Med Chem Lett 20: 7349-53 (2010) Article DOI: 10.1016/j.bmcl.2010.10.056 BindingDB Entry DOI: 10.7270/Q21836QQ
					More data for this Ligand-Target Pair
Cyclooxygenase-1 (Oryctolagus cuniculus)	BDBM50331900 (CHEMBL1289227 | E-6-Chloro-3-[[4-(methylsulfonyl)p...) Show SMILES CS(=O)(=O)c1ccc(\C=C2\C(=O)Nc3cc(Cl)ccc23)cc1 Show InChI InChI=1S/C16H12ClNO3S/c1-22(20,21)12-5-2-10(3-6-12)8-14-13-7-4-11(17)9-15(13)18-16(14)19/h2-9H,1H3,(H,18,19)/b14-8+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of c...				Bioorg Med Chem Lett 20: 7349-53 (2010) Article DOI: 10.1016/j.bmcl.2010.10.056 BindingDB Entry DOI: 10.7270/Q21836QQ
					More data for this Ligand-Target Pair