BindingDB logo
myBDB logout

null

SMILES: CN1[C@@H](C[C@@H](n2ncc(C(=O)NC34CC5CC(CC(C5)C3)C4)c12)C(F)(F)F)c1ccccc1

InChI Key: InChIKey=SVRNTBAAYAVMII-ONZSLIJNSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331948   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Extracellular calcium-sensing receptor


(Homo sapiens (Human))		BDBM50331948
PNG
(CHEMBL1289463 | N-(1-Adamantyl)-4-methyl-7-trifluo...)
Show SMILES CN1[C@@H](C[C@@H](n2ncc(C(=O)NC34CC5CC(CC(C5)C3)C4)c12)C(F)(F)F)c1ccccc1 |r,THB:17:16:13:19.18.20,17:18:15.16.21:13,20:18:15:21.12.13,20:12:15:19.17.18,11:12:15:19.17.18|
Show InChI InChI=1S/C25H29F3N4O/c1-31-20(18-5-3-2-4-6-18)10-21(25(26,27)28)32-23(31)19(14-29-32)22(33)30-24-11-15-7-16(12-24)9-17(8-15)13-24/h2-6,14-17,20-21H,7-13H2,1H3,(H,30,33)/t15?,16?,17?,20-,21+,24?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonist activity at CaSR expressed in CHO cells assessed as [35S]-GTPgammaS binding by scintillation counting

Bioorg Med Chem 18: 8501-11 (2010)


Article DOI: 10.1016/j.bmc.2010.10.035
BindingDB Entry DOI: 10.7270/Q2CJ8DRD
More data for this
Ligand-Target Pair