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SMILES: Clc1ccc(N2CCN(CC2)C(=O)COCc2cccnc2)c(Cl)c1

InChI Key: InChIKey=CCCYRBOSIZXPIH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331992   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50331992
PNG
(1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyridi...)
Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2cccnc2)c(Cl)c1
Show InChI InChI=1S/C18H19Cl2N3O2/c19-15-3-4-17(16(20)10-15)22-6-8-23(9-7-22)18(24)13-25-12-14-2-1-5-21-11-14/h1-5,10-11H,6-9,12-13H2
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Article
PubMed
n/an/an/an/a 1.09E+3n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay

Bioorg Med Chem Lett 20: 7381-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.036
BindingDB Entry DOI: 10.7270/Q27S7P13
More data for this
Ligand-Target Pair