BDBM50331998 1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrimidin-4-ylmethoxy)ethanone::CHEMBL1290218

SMILES: Clc1ccc(N2CCN(CC2)C(=O)COCc2ccncn2)c(Cl)c1

InChI Key: InChIKey=HZQBESXNBCILDZ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50331998   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50331998 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(pyrimi...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2ccncn2)c(Cl)c1 Show InChI InChI=1S/C17H18Cl2N4O2/c18-13-1-2-16(15(19)9-13)22-5-7-23(8-6-22)17(24)11-25-10-14-3-4-20-12-21-14/h1-4,9,12H,5-8,10-11H2	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair