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SMILES: Clc1cccc(c1)N1CCN(CC1)C(=O)COCc1ccccc1

InChI Key: InChIKey=CLYGEPUTTXMDBI-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50332003   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50332003
PNG
(2-(benzyloxy)-1-(4-(3-chlorophenyl)piperazin-1-yl)...)
Show SMILES Clc1cccc(c1)N1CCN(CC1)C(=O)COCc1ccccc1
Show InChI InChI=1S/C19H21ClN2O2/c20-17-7-4-8-18(13-17)21-9-11-22(12-10-21)19(23)15-24-14-16-5-2-1-3-6-16/h1-8,13H,9-12,14-15H2
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MMDB

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Similars
Article
PubMed
n/an/an/an/a 6.70E+3n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay

Bioorg Med Chem Lett 20: 7381-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.036
BindingDB Entry DOI: 10.7270/Q27S7P13
More data for this
Ligand-Target Pair