BDBM50332005 1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazol-2-ylmethoxy)ethanone::CHEMBL1290442

SMILES: Clc1ccc(N2CCN(CC2)C(=O)COCc2nccs2)c(Cl)c1

InChI Key: InChIKey=MZRRIRREJPBTPH-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50332005   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50332005 (1-(4-(2,4-dichlorophenyl)piperazin-1-yl)-2-(thiazo...) Show SMILES Clc1ccc(N2CCN(CC2)C(=O)COCc2nccs2)c(Cl)c1 Show InChI InChI=1S/C16H17Cl2N3O2S/c17-12-1-2-14(13(18)9-12)20-4-6-21(7-5-20)16(22)11-23-10-15-19-3-8-24-15/h1-3,8-9H,4-7,10-11H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.03E+4	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay				Bioorg Med Chem Lett 20: 7381-4 (2010) Article DOI: 10.1016/j.bmcl.2010.10.036 BindingDB Entry DOI: 10.7270/Q27S7P13
					More data for this Ligand-Target Pair