BindingDB PrimarySearch

BDBM50332481 (R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)methoxy)phenyl)-2-oxopyrrolidin-1-yl)-N-hydroxy-3-methylbutanamide::CHEMBL1630098

SMILES: CC(C)[C@@H](N1CC[C@](N)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO

InChI Key: InChIKey=VINTZLVANMVXOH-ZEQKJWHPSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50332481
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50332481 ((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human MMP9 in cell-free system by fluorescent spectroscopy				Bioorg Med Chem 18: 8618-29 (2010) Article DOI: 10.1016/j.bmc.2010.10.006 BindingDB Entry DOI: 10.7270/Q2NV9JHW
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50332481 ((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human TACE by fluorescent spectroscopy				Bioorg Med Chem 18: 8618-29 (2010) Article DOI: 10.1016/j.bmc.2010.10.006 BindingDB Entry DOI: 10.7270/Q2NV9JHW
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM50332481 ((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human TACE by fluorescent spectroscopy				Bioorg Med Chem 18: 8618-29 (2010) Article DOI: 10.1016/j.bmc.2010.10.006 BindingDB Entry DOI: 10.7270/Q2NV9JHW
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50332481 ((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human MMP3 in cell-free system by fluorescent spectroscopy				Bioorg Med Chem 18: 8618-29 (2010) Article DOI: 10.1016/j.bmc.2010.10.006 BindingDB Entry DOI: 10.7270/Q2NV9JHW
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50332481 ((R)-2-((R)-3-amino-3-(4-((2-methylquinolin-4-yl)me...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.93E+6	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of human MMP1 in cell-free system by fluorescent spectroscopy				Bioorg Med Chem 18: 8618-29 (2010) Article DOI: 10.1016/j.bmc.2010.10.006 BindingDB Entry DOI: 10.7270/Q2NV9JHW
Yonsei University Curated by ChEMBL					More data for this Ligand-Target Pair