BDBM50332969 7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one::CHEMBL1631858

SMILES: Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1

InChI Key: InChIKey=ZYGZDPKEZBLAHD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50332969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332969 (7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:4| Show InChI InChI=1S/C22H16F3N3O/c1-13-9-19-20(11-17(13)22(23,24)25)28-21(29)12-18(27-19)16-4-2-3-15(10-16)14-5-7-26-8-6-14/h2-11H,12H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50332969 (7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:4| Show InChI InChI=1S/C22H16F3N3O/c1-13-9-19-20(11-17(13)22(23,24)25)28-21(29)12-18(27-19)16-4-2-3-15(10-16)14-5-7-26-8-6-14/h2-11H,12H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50332969 (7-methyl-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:4| Show InChI InChI=1S/C22H16F3N3O/c1-13-9-19-20(11-17(13)22(23,24)25)28-21(29)12-18(27-19)16-4-2-3-15(10-16)14-5-7-26-8-6-14/h2-11H,12H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd Curated by ChEMBL					Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...				Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R
					More data for this Ligand-Target Pair