null

SMILES: c1ccc(nc1)C#Cc1n[nH]c2ccccc12

InChI Key: InChIKey=PDHRIFYPBBUERI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333025   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50333025 (3-(Pyridin-2-ylethynyl)-1H-indazole | CHEMBL163189...) Show SMILES c1ccc(nc1)C#Cc1n[nH]c2ccccc12 Show InChI InChI=1S/C14H9N3/c1-2-7-13-12(6-1)14(17-16-13)9-8-11-5-3-4-10-15-11/h1-7,10H,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of mTORC1 expressed in HEK293 cells assessed as PRAS40 Ser183 phosphorylation level by LanthaScreen cellular assay				J Med Chem 53: 8368-8375 (2010) Article DOI: 10.1021/jm100825h BindingDB Entry DOI: 10.7270/Q2NP24PS
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50333025 (3-(Pyridin-2-ylethynyl)-1H-indazole | CHEMBL163189...) Show SMILES c1ccc(nc1)C#Cc1n[nH]c2ccccc12 Show InChI InChI=1S/C14H9N3/c1-2-7-13-12(6-1)14(17-16-13)9-8-11-5-3-4-10-15-11/h1-7,10H,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha by LanthaScreen Eu kinase binding assay				J Med Chem 53: 8368-8375 (2010) Article DOI: 10.1021/jm100825h BindingDB Entry DOI: 10.7270/Q2NP24PS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50333025 (3-(Pyridin-2-ylethynyl)-1H-indazole | CHEMBL163189...) Show SMILES c1ccc(nc1)C#Cc1n[nH]c2ccccc12 Show InChI InChI=1S/C14H9N3/c1-2-7-13-12(6-1)14(17-16-13)9-8-11-5-3-4-10-15-11/h1-7,10H,(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of mTOR by LanthaScreen Eu kinase binding assay				J Med Chem 53: 8368-8375 (2010) Article DOI: 10.1021/jm100825h BindingDB Entry DOI: 10.7270/Q2NP24PS
					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50333025 (3-(Pyridin-2-ylethynyl)-1H-indazole | CHEMBL163189...) Show SMILES c1ccc(nc1)C#Cc1n[nH]c2ccccc12 Show InChI InChI=1S/C14H9N3/c1-2-7-13-12(6-1)14(17-16-13)9-8-11-5-3-4-10-15-11/h1-7,10H,(H,16,17)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of PDK1 by Z'-LYTE kinase activity assay				J Med Chem 53: 8368-8375 (2010) Article DOI: 10.1021/jm100825h BindingDB Entry DOI: 10.7270/Q2NP24PS
					More data for this Ligand-Target Pair