BDBM50333177 1-{[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]acetyl}-L-prolinamide dihydrochloride::CHEMBL1644850

SMILES: CC(C)Cc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(-c2ccc(C)cc2)c1CN

InChI Key: InChIKey=ILRWGNNTDUTQFY-QFIPXVFZSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50333177   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50333177 (1-{[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-...) Show SMILES CC(C)Cc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(-c2ccc(C)cc2)c1CN |r| Show InChI InChI=1S/C25H34N4O2/c1-15(2)12-21-20(14-26)24(18-9-7-16(3)8-10-18)19(17(4)28-21)13-23(30)29-11-5-6-22(29)25(27)31/h7-10,15,22H,5-6,11-14,26H2,1-4H3,(H2,27,31)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of DDP4 in human Caco2 cells after 60 mins by spectrophotometry				Bioorg Med Chem 19: 172-85 (2011) Article DOI: 10.1016/j.bmc.2010.11.038 BindingDB Entry DOI: 10.7270/Q2TB174K
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50333177 (1-{[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-...) Show SMILES CC(C)Cc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(-c2ccc(C)cc2)c1CN |r| Show InChI InChI=1S/C25H34N4O2/c1-15(2)12-21-20(14-26)24(18-9-7-16(3)8-10-18)19(17(4)28-21)13-23(30)29-11-5-6-22(29)25(27)31/h7-10,15,22H,5-6,11-14,26H2,1-4H3,(H2,27,31)/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human DDP9 expressed in HEK293-F cells after 90 mins by spectrophotometry				Bioorg Med Chem 19: 172-85 (2011) Article DOI: 10.1016/j.bmc.2010.11.038 BindingDB Entry DOI: 10.7270/Q2TB174K
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50333177 (1-{[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-...) Show SMILES CC(C)Cc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(-c2ccc(C)cc2)c1CN |r| Show InChI InChI=1S/C25H34N4O2/c1-15(2)12-21-20(14-26)24(18-9-7-16(3)8-10-18)19(17(4)28-21)13-23(30)29-11-5-6-22(29)25(27)31/h7-10,15,22H,5-6,11-14,26H2,1-4H3,(H2,27,31)/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human DDP8 expressed in HEK293-F cells after 90 mins by spectrophotometry				Bioorg Med Chem 19: 172-85 (2011) Article DOI: 10.1016/j.bmc.2010.11.038 BindingDB Entry DOI: 10.7270/Q2TB174K
					More data for this Ligand-Target Pair
Dipeptidyl peptidase II (Rattus norvegicus)	BDBM50333177 (1-{[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-...) Show SMILES CC(C)Cc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(-c2ccc(C)cc2)c1CN |r| Show InChI InChI=1S/C25H34N4O2/c1-15(2)12-21-20(14-26)24(18-9-7-16(3)8-10-18)19(17(4)28-21)13-23(30)29-11-5-6-22(29)25(27)31/h7-10,15,22H,5-6,11-14,26H2,1-4H3,(H2,27,31)/t22-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of rat kidney DDP2 after 60 mins by spectrophotometry				Bioorg Med Chem 19: 172-85 (2011) Article DOI: 10.1016/j.bmc.2010.11.038 BindingDB Entry DOI: 10.7270/Q2TB174K
					More data for this Ligand-Target Pair