BindingDB PrimarySearch

BDBM50334085 2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide::CHEMBL1644812

SMILES: CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O

InChI Key: InChIKey=KHBUKOVUBUJCGM-UHFFFAOYSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50334085
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
Cephalon, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
Cephalon, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of IR kinase				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
Cephalon, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of human c-Met in human GTL16 cells by cell-based assay				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
Cephalon, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
Cephalon, Inc Curated by ChEMBL					More data for this Ligand-Target Pair