BDBM50334087 2-{5-Chloro-2-[1-(2-methoxy-ethyl)-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino]-pyrimidin-4-ylamino}-3-fluoro-N-methyl-benzamide::CHEMBL1644815

SMILES: CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CCOC)C(=O)CCC3(C)C)ncc1Cl

InChI Key: InChIKey=PRRFEHPXFCRKNK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50334087   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334087 (2-{5-Chloro-2-[1-(2-methoxy-ethyl)-5,5-dimethyl-2-...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CCOC)C(=O)CCC3(C)C)ncc1Cl Show InChI InChI=1S/C27H30ClFN6O3/c1-27(2)11-10-22(36)35(12-13-38-4)21-14-16(8-9-18(21)27)32-26-31-15-19(28)24(34-26)33-23-17(25(37)30-3)6-5-7-20(23)29/h5-9,14-15H,10-13H2,1-4H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50334087 (2-{5-Chloro-2-[1-(2-methoxy-ethyl)-5,5-dimethyl-2-...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CCOC)C(=O)CCC3(C)C)ncc1Cl Show InChI InChI=1S/C27H30ClFN6O3/c1-27(2)11-10-22(36)35(12-13-38-4)21-14-16(8-9-18(21)27)32-26-31-15-19(28)24(34-26)33-23-17(25(37)30-3)6-5-7-20(23)29/h5-9,14-15H,10-13H2,1-4H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	231	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of IR kinase				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334087 (2-{5-Chloro-2-[1-(2-methoxy-ethyl)-5,5-dimethyl-2-...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CCOC)C(=O)CCC3(C)C)ncc1Cl Show InChI InChI=1S/C27H30ClFN6O3/c1-27(2)11-10-22(36)35(12-13-38-4)21-14-16(8-9-18(21)27)32-26-31-15-19(28)24(34-26)33-23-17(25(37)30-3)6-5-7-20(23)29/h5-9,14-15H,10-13H2,1-4H3,(H,30,37)(H2,31,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of human c-Met in human GTL16 cells by cell-based assay				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair