BindingDB PrimarySearch

BDBM50334918 (R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquinolin-4-amine::CHEMBL1643512

SMILES: N[C@@H]1CCN(c2ccc(Cl)c(Cl)c2)c2ccccc12

InChI Key: InChIKey=OBKCQTGBMZHBFE-CQSZACIVSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50334918
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant 5HT transporter				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant norepinephrine transporter				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of human recombinant dopamine transporter				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of human ERG				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of CYP2C19				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of CYP2D6				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of CYP3A4				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50334918 ((R)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroquino...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of CYP2C9				Bioorg Med Chem Lett 21: 520-3 (2010) Article DOI: 10.1016/j.bmcl.2010.10.086 BindingDB Entry DOI: 10.7270/Q2DJ5FWS
Sunovion Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair