BDBM50335167 2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzimidazol-2-yl)-1-oxa-3-azaspiro[4.5]dec-2-ene::CHEMBL1650507

SMILES: FC(F)(F)c1ccccc1-c1ccc2nc([nH]c2c1)C1=NCC2(CCCCC2)O1

InChI Key: InChIKey=AFZPEAHVTPPURB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50335167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Canis lupus familiaris (Dog))	BDBM50335167 (2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzimidazol-2...) Show SMILES FC(F)(F)c1ccccc1-c1ccc2nc([nH]c2c1)C1=NCC2(CCCCC2)O1 |t:22| Show InChI InChI=1S/C22H20F3N3O/c23-22(24,25)16-7-3-2-6-15(16)14-8-9-17-18(12-14)28-19(27-17)20-26-13-21(29-20)10-4-1-5-11-21/h2-3,6-9,12H,1,4-5,10-11,13H2,(H,27,28)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assay				J Med Chem 54: 233-47 (2011) Article DOI: 10.1021/jm101075v BindingDB Entry DOI: 10.7270/Q20C4WRJ
					More data for this Ligand-Target Pair