BDBM50335211 5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine::CHEMBL1650697
SMILES: C[C@H](Nc1ncc(F)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1
InChI Key: InChIKey=RDRRGPBIENGEQJ-QMMMGPOBSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50335211 (5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Curated by ChEMBL | Assay Description Inhibition of JAK3 using 5 mM of ATP | J Med Chem 54: 262-76 (2011) Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50335211 (5-Fluoro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Curated by ChEMBL | Assay Description Inhibition of JAK2 using 5 mM of ATP | J Med Chem 54: 262-76 (2011) Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM | |||||||||||
More data for this Ligand-Target Pair |