BDBM50335510 1-(3-fluoro-4-(5-(2-phenylpropan-2-yl)thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid::CHEMBL1651860

SMILES: CC(C)(c1ccccc1)c1ccc2nc(sc2n1)-c1ccc(CN2CC(C2)C(O)=O)cc1F

InChI Key: InChIKey=QUWSDCUDDZSZRI-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50335510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human))	BDBM50335510 (1-(3-fluoro-4-(5-(2-phenylpropan-2-yl)thiazolo[5,4...) Show SMILES CC(C)(c1ccccc1)c1ccc2nc(sc2n1)-c1ccc(CN2CC(C2)C(O)=O)cc1F Show InChI InChI=1S/C26H24FN3O2S/c1-26(2,18-6-4-3-5-7-18)22-11-10-21-24(29-22)33-23(28-21)19-9-8-16(12-20(19)27)13-30-14-17(15-30)25(31)32/h3-12,17H,13-15H2,1-2H3,(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Induction of human GFP-tagged chimeric S1P1R internalization in human U2Os cells by fluorescence microscopy				ACS Med Chem Lett 2: 107-112 (2011) Article DOI: 10.1021/ml100306h BindingDB Entry DOI: 10.7270/Q2H995G4
					More data for this Ligand-Target Pair
Sphingosine 1-phosphate receptor 3 (Homo sapiens (Human))	BDBM50335510 (1-(3-fluoro-4-(5-(2-phenylpropan-2-yl)thiazolo[5,4...) Show SMILES CC(C)(c1ccccc1)c1ccc2nc(sc2n1)-c1ccc(CN2CC(C2)C(O)=O)cc1F Show InChI InChI=1S/C26H24FN3O2S/c1-26(2,18-6-4-3-5-7-18)22-11-10-21-24(29-22)33-23(28-21)19-9-8-16(12-20(19)27)13-30-14-17(15-30)25(31)32/h3-12,17H,13-15H2,1-2H3,(H,31,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human S1P3R expressed in CHO cells by Ca(2+) mobilization assay				ACS Med Chem Lett 2: 107-112 (2011) Article DOI: 10.1021/ml100306h BindingDB Entry DOI: 10.7270/Q2H995G4
					More data for this Ligand-Target Pair