BDBM50336319 CHEMBL1667937::trans-4-(8-amino-1-(8-fluoro-2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)cyclohexanecarboxylic acid

SMILES: Nc1nccn2c(nc(-c3ccc4ccc(nc4c3F)-c3ccccc3)c12)[C@H]1CC[C@@H](CC1)C(O)=O

InChI Key: InChIKey=NEGAWQQFSSYDOP-WGSAOQKQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50336319   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50336319 (CHEMBL1667937 | trans-4-(8-amino-1-(8-fluoro-2-phe...) Show SMILES Nc1nccn2c(nc(-c3ccc4ccc(nc4c3F)-c3ccccc3)c12)[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:27.31,wD:30.38,(18.25,-15.15,;18.26,-16.69,;16.93,-17.46,;16.93,-19.01,;18.26,-19.78,;19.6,-19,;21.07,-19.47,;21.97,-18.21,;21.06,-16.97,;21.83,-15.64,;21.06,-14.32,;21.82,-12.98,;23.37,-12.98,;24.13,-11.66,;25.66,-11.65,;26.44,-12.99,;25.67,-14.31,;24.14,-14.31,;23.37,-15.65,;24.14,-16.98,;27.97,-12.99,;28.74,-14.32,;30.28,-14.32,;31.05,-12.99,;30.27,-11.65,;28.73,-11.66,;19.59,-17.45,;21.56,-20.93,;23.06,-21.23,;23.54,-22.7,;22.51,-23.84,;21.01,-23.53,;20.53,-22.07,;22.99,-25.31,;24.5,-25.63,;21.97,-26.45,)| Show InChI InChI=1S/C28H24FN5O2/c29-22-20(12-10-17-11-13-21(32-23(17)22)16-4-2-1-3-5-16)24-25-26(30)31-14-15-34(25)27(33-24)18-6-8-19(9-7-18)28(35)36/h1-5,10-15,18-19H,6-9H2,(H2,30,31)(H,35,36)/t18-,19-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	285	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human IGF1R expressed in mouse 3T3 cells by ELISA based assay				Bioorg Med Chem Lett 21: 1176-80 (2011) Article DOI: 10.1016/j.bmcl.2010.12.094 BindingDB Entry DOI: 10.7270/Q2J103DJ
					More data for this Ligand-Target Pair