BDBM50336502 10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one::CHEMBL467903

SMILES: CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl

InChI Key: InChIKey=XGFVEPUAULNKKW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50336502   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human))	BDBM50336502 (10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3...) Show SMILES CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl |c:14| Show InChI InChI=1S/C23H22Cl2N2O2/c1-13(28)27-19-7-5-4-6-17(19)26-18-11-23(2,3)12-20(29)21(18)22(27)15-9-8-14(24)10-16(15)25/h4-10,21-22H,11-12H2,1-3H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Tibotec BVBA Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha				Antimicrob Agents Chemother 52: 4420-31 (2008) Article DOI: 10.1128/AAC.00669-08 BindingDB Entry DOI: 10.7270/Q26M3732
					More data for this Ligand-Target Pair
DNA polymerase gamma subunit 1 (Homo sapiens (Human))	BDBM50336502 (10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3...) Show SMILES CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl |c:14| Show InChI InChI=1S/C23H22Cl2N2O2/c1-13(28)27-19-7-5-4-6-17(19)26-18-11-23(2,3)12-20(29)21(18)22(27)15-9-8-14(24)10-16(15)25/h4-10,21-22H,11-12H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Tibotec BVBA Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase gamma				Antimicrob Agents Chemother 52: 4420-31 (2008) Article DOI: 10.1128/AAC.00669-08 BindingDB Entry DOI: 10.7270/Q26M3732
					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50336502 (10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3...) Show SMILES CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl |c:14| Show InChI InChI=1S/C23H22Cl2N2O2/c1-13(28)27-19-7-5-4-6-17(19)26-18-11-23(2,3)12-20(29)21(18)22(27)15-9-8-14(24)10-16(15)25/h4-10,21-22H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Tibotec BVBA Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase beta				Antimicrob Agents Chemother 52: 4420-31 (2008) Article DOI: 10.1128/AAC.00669-08 BindingDB Entry DOI: 10.7270/Q26M3732
					More data for this Ligand-Target Pair