BDBM50336806 1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-yl)piperazine-2,5-dione dihydrochloride::CHEMBL1672113
SMILES: CC(C)Cc1nc2ccc(cc2c(-c2ccc(C)cc2)c1CN)N1CC(=O)NCC1=O
InChI Key: InChIKey=VHNILDKAFINLSQ-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50336806 (1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysis | Bioorg Med Chem 19: 4482-98 (2011) Article DOI: 10.1016/j.bmc.2011.06.032 BindingDB Entry DOI: 10.7270/Q2P26ZGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase II (Rattus norvegicus) | BDBM50336806 (1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of rat kidney Dipeptidyl peptidase-2 using H-Lys-Ala-pNA.2HCl as substrate after 60 mins by microplate reader analysis | Bioorg Med Chem 19: 4482-98 (2011) Article DOI: 10.1016/j.bmc.2011.06.032 BindingDB Entry DOI: 10.7270/Q2P26ZGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM50336806 (1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of DPP4 in human Caco2 cells after 60 mins | J Med Chem 54: 831-50 (2012) Article DOI: 10.1021/jm101236h BindingDB Entry DOI: 10.7270/Q2QR4Z4M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 9 (Homo sapiens (Human)) | BDBM50336806 (1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of FLAG-tagged human Dipeptidyl peptidase-9 expressed in 293-F cells using Gly-Pro-pNA.Tos as substrate after 90 mins by microplate reader... | Bioorg Med Chem 19: 4482-98 (2011) Article DOI: 10.1016/j.bmc.2011.06.032 BindingDB Entry DOI: 10.7270/Q2P26ZGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM50336806 (1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Inhibition of FLAG-tagged human Dipeptidyl peptidase-8 expressed in 293-F cells using Gly-Pro-pNA.Tos as substrate after 90 mins by microplate reader... | Bioorg Med Chem 19: 4482-98 (2011) Article DOI: 10.1016/j.bmc.2011.06.032 BindingDB Entry DOI: 10.7270/Q2P26ZGN | |||||||||||
More data for this Ligand-Target Pair |