BDBM50336916 3-chloro-N-(4-chlorophenyl)-5-(4-methyl-1-propyl-1H-imidazol-2-yl)pyridin-2-amine::CHEMBL1672439

SMILES: CCCn1cc(C)nc1-c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1

InChI Key: InChIKey=DGGVSYPBSIIZRQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50336916   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50336916 (3-chloro-N-(4-chlorophenyl)-5-(4-methyl-1-propyl-1...) Show SMILES CCCn1cc(C)nc1-c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1 Show InChI InChI=1S/C18H18Cl2N4/c1-3-8-24-11-12(2)22-18(24)13-9-16(20)17(21-10-13)23-15-6-4-14(19)5-7-15/h4-7,9-11H,3,8H2,1-2H3,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assay				ACS Med Chem Lett 2: 58-62 (2011) Article DOI: 10.1021/ml100215b BindingDB Entry DOI: 10.7270/Q22R3RZM
					More data for this Ligand-Target Pair