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SMILES: Cc1cn(C)c(n1)-c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1

InChI Key: InChIKey=GXRSOTZPZCTLQG-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50336920   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50336920
PNG
(3-chloro-N-(4-chlorophenyl)-5-(1,4-dimethyl-1H-imi...)
Show SMILES Cc1cn(C)c(n1)-c1cnc(Nc2ccc(Cl)cc2)c(Cl)c1
Show InChI InChI=1S/C16H14Cl2N4/c1-10-9-22(2)16(20-10)11-7-14(18)15(19-8-11)21-13-5-3-12(17)4-6-13/h3-9H,1-2H3,(H,19,21)
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Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu5 receptor assessed as inhibition of glutamate-induced calcium flux by cell based assay

ACS Med Chem Lett 2: 58-62 (2011)


Article DOI: 10.1021/ml100215b
BindingDB Entry DOI: 10.7270/Q22R3RZM
More data for this
Ligand-Target Pair