BDBM50337674 5-benzyl-2-(4-(2-chloro-5-aminobenzyl)piperazin-1-yl)pyrimidine::CHEMBL1683285

SMILES: Nc1ccc(Cl)c(CN2CCN(CC2)c2ncc(Cc3ccccc3)cn2)c1

InChI Key: InChIKey=ZZSAVONEIVIKBP-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50337674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM50337674 (5-benzyl-2-(4-(2-chloro-5-aminobenzyl)piperazin-1-...) Show SMILES Nc1ccc(Cl)c(CN2CCN(CC2)c2ncc(Cc3ccccc3)cn2)c1 Show InChI InChI=1S/C22H24ClN5/c23-21-7-6-20(24)13-19(21)16-27-8-10-28(11-9-27)22-25-14-18(15-26-22)12-17-4-2-1-3-5-17/h1-7,13-15H,8-12,16,24H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of the Pacific Curated by ChEMBL					Assay Description Binding affinity to Bcl-xL after 2 hrs by fluorescein-labeled Bak-BH3 peptide competition binding assay				Bioorg Med Chem Lett 21: 1325-8 (2011) Article DOI: 10.1016/j.bmcl.2011.01.054 BindingDB Entry DOI: 10.7270/Q2T153XN
					More data for this Ligand-Target Pair