BDBM50338061 CHEMBL1684514::N-(3-(6-methyl-1H-indol-2-yl)-1H-indazol-6-yl)cyclohexanecarboxamide

SMILES: Cc1ccc2cc([nH]c2c1)-c1n[nH]c2cc(NC(=O)C3CCCCC3)ccc12

InChI Key: InChIKey=OXYQYPAUFLWFAB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50338061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human))	BDBM50338061 (CHEMBL1684514 | N-(3-(6-methyl-1H-indol-2-yl)-1H-i...) Show SMILES Cc1ccc2cc([nH]c2c1)-c1n[nH]c2cc(NC(=O)C3CCCCC3)ccc12 Show InChI InChI=1S/C23H24N4O/c1-14-7-8-16-12-21(25-19(16)11-14)22-18-10-9-17(13-20(18)26-27-22)24-23(28)15-5-3-2-4-6-15/h7-13,15,25H,2-6H2,1H3,(H,24,28)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nycomed GmbH Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assay				Bioorg Med Chem Lett 21: 1852-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.035 BindingDB Entry DOI: 10.7270/Q2MC90BW
					More data for this Ligand-Target Pair