BDBM50338414 CHEMBL1683120::trans-(S)-1-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide

SMILES: N[C@H](Cc1cc(F)ccc1F)[C@H]1CC[C@@H](CC1)N1CCC[C@@H](C1)C(N)=O

InChI Key: InChIKey=FBQPVRNOIUERMB-AGGDQXJMSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50338414   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50338414 (CHEMBL1683120 | trans-(S)-1-(4-((R)-1-amino-2-(2,5...) Show SMILES N[C@H](Cc1cc(F)ccc1F)[C@H]1CC[C@@H](CC1)N1CCC[C@@H](C1)C(N)=O |r,wU:1.0,14.18,wD:11.17,21.25,(-5.48,-4.14,;-5.48,-5.68,;-6.81,-6.45,;-8.14,-5.68,;-8.15,-4.13,;-9.48,-3.37,;-9.49,-1.83,;-10.81,-4.14,;-10.82,-5.68,;-9.48,-6.45,;-9.48,-7.99,;-4.14,-6.45,;-4.15,-7.98,;-2.82,-8.75,;-1.48,-7.98,;-1.48,-6.44,;-2.82,-5.67,;-.15,-8.76,;1.18,-7.98,;2.51,-8.76,;2.51,-10.3,;1.16,-11.06,;-.16,-10.29,;1.15,-12.6,;2.48,-13.38,;-.19,-13.37,)| Show InChI InChI=1S/C20H29F2N3O/c21-16-5-8-18(22)15(10-16)11-19(23)13-3-6-17(7-4-13)25-9-1-2-14(12-25)20(24)26/h5,8,10,13-14,17,19H,1-4,6-7,9,11-12,23H2,(H2,24,26)/t13-,14-,17-,19+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of FAP				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50338414 (CHEMBL1683120 | trans-(S)-1-(4-((R)-1-amino-2-(2,5...) Show SMILES N[C@H](Cc1cc(F)ccc1F)[C@H]1CC[C@@H](CC1)N1CCC[C@@H](C1)C(N)=O |r,wU:1.0,14.18,wD:11.17,21.25,(-5.48,-4.14,;-5.48,-5.68,;-6.81,-6.45,;-8.14,-5.68,;-8.15,-4.13,;-9.48,-3.37,;-9.49,-1.83,;-10.81,-4.14,;-10.82,-5.68,;-9.48,-6.45,;-9.48,-7.99,;-4.14,-6.45,;-4.15,-7.98,;-2.82,-8.75,;-1.48,-7.98,;-1.48,-6.44,;-2.82,-5.67,;-.15,-8.76,;1.18,-7.98,;2.51,-8.76,;2.51,-10.3,;1.16,-11.06,;-.16,-10.29,;1.15,-12.6,;2.48,-13.38,;-.19,-13.37,)| Show InChI InChI=1S/C20H29F2N3O/c21-16-5-8-18(22)15(10-16)11-19(23)13-3-6-17(7-4-13)25-9-1-2-14(12-25)20(24)26/h5,8,10,13-14,17,19H,1-4,6-7,9,11-12,23H2,(H2,24,26)/t13-,14-,17-,19+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of QPP				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50338414 (CHEMBL1683120 | trans-(S)-1-(4-((R)-1-amino-2-(2,5...) Show SMILES N[C@H](Cc1cc(F)ccc1F)[C@H]1CC[C@@H](CC1)N1CCC[C@@H](C1)C(N)=O |r,wU:1.0,14.18,wD:11.17,21.25,(-5.48,-4.14,;-5.48,-5.68,;-6.81,-6.45,;-8.14,-5.68,;-8.15,-4.13,;-9.48,-3.37,;-9.49,-1.83,;-10.81,-4.14,;-10.82,-5.68,;-9.48,-6.45,;-9.48,-7.99,;-4.14,-6.45,;-4.15,-7.98,;-2.82,-8.75,;-1.48,-7.98,;-1.48,-6.44,;-2.82,-5.67,;-.15,-8.76,;1.18,-7.98,;2.51,-8.76,;2.51,-10.3,;1.16,-11.06,;-.16,-10.29,;1.15,-12.6,;2.48,-13.38,;-.19,-13.37,)| Show InChI InChI=1S/C20H29F2N3O/c21-16-5-8-18(22)15(10-16)11-19(23)13-3-6-17(7-4-13)25-9-1-2-14(12-25)20(24)26/h5,8,10,13-14,17,19H,1-4,6-7,9,11-12,23H2,(H2,24,26)/t13-,14-,17-,19+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP4				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50338414 (CHEMBL1683120 | trans-(S)-1-(4-((R)-1-amino-2-(2,5...) Show SMILES N[C@H](Cc1cc(F)ccc1F)[C@H]1CC[C@@H](CC1)N1CCC[C@@H](C1)C(N)=O |r,wU:1.0,14.18,wD:11.17,21.25,(-5.48,-4.14,;-5.48,-5.68,;-6.81,-6.45,;-8.14,-5.68,;-8.15,-4.13,;-9.48,-3.37,;-9.49,-1.83,;-10.81,-4.14,;-10.82,-5.68,;-9.48,-6.45,;-9.48,-7.99,;-4.14,-6.45,;-4.15,-7.98,;-2.82,-8.75,;-1.48,-7.98,;-1.48,-6.44,;-2.82,-5.67,;-.15,-8.76,;1.18,-7.98,;2.51,-8.76,;2.51,-10.3,;1.16,-11.06,;-.16,-10.29,;1.15,-12.6,;2.48,-13.38,;-.19,-13.37,)| Show InChI InChI=1S/C20H29F2N3O/c21-16-5-8-18(22)15(10-16)11-19(23)13-3-6-17(7-4-13)25-9-1-2-14(12-25)20(24)26/h5,8,10,13-14,17,19H,1-4,6-7,9,11-12,23H2,(H2,24,26)/t13-,14-,17-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP8				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50338414 (CHEMBL1683120 | trans-(S)-1-(4-((R)-1-amino-2-(2,5...) Show SMILES N[C@H](Cc1cc(F)ccc1F)[C@H]1CC[C@@H](CC1)N1CCC[C@@H](C1)C(N)=O |r,wU:1.0,14.18,wD:11.17,21.25,(-5.48,-4.14,;-5.48,-5.68,;-6.81,-6.45,;-8.14,-5.68,;-8.15,-4.13,;-9.48,-3.37,;-9.49,-1.83,;-10.81,-4.14,;-10.82,-5.68,;-9.48,-6.45,;-9.48,-7.99,;-4.14,-6.45,;-4.15,-7.98,;-2.82,-8.75,;-1.48,-7.98,;-1.48,-6.44,;-2.82,-5.67,;-.15,-8.76,;1.18,-7.98,;2.51,-8.76,;2.51,-10.3,;1.16,-11.06,;-.16,-10.29,;1.15,-12.6,;2.48,-13.38,;-.19,-13.37,)| Show InChI InChI=1S/C20H29F2N3O/c21-16-5-8-18(22)15(10-16)11-19(23)13-3-6-17(7-4-13)25-9-1-2-14(12-25)20(24)26/h5,8,10,13-14,17,19H,1-4,6-7,9,11-12,23H2,(H2,24,26)/t13-,14-,17-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of DPP9				Bioorg Med Chem Lett 21: 1880-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.060 BindingDB Entry DOI: 10.7270/Q2SX6DJG
					More data for this Ligand-Target Pair