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SMILES: COc1ccc2OCC(Cc2c1)c1nc2c(F)cc(cc2c(=O)[nH]1)-c1cn[nH]c1

InChI Key: InChIKey=OPFIIKDBLOLKPJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50338715   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Rho-associated protein kinase 2


(Homo sapiens (Human))		BDBM50338715
PNG
(8-fluoro-2-(6-methoxychroman-3-yl)-6-(1H-pyrazol-4...)
Show SMILES COc1ccc2OCC(Cc2c1)c1nc2c(F)cc(cc2c(=O)[nH]1)-c1cn[nH]c1
Show InChI InChI=1S/C21H17FN4O3/c1-28-15-2-3-18-12(5-15)4-13(10-29-18)20-25-19-16(21(27)26-20)6-11(7-17(19)22)14-8-23-24-9-14/h2-3,5-9,13H,4,10H2,1H3,(H,23,24)(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 104n/an/an/an/an/an/a



Translational Research Institute

Curated by ChEMBL


Assay Description
Inhibition of ROCK2 by HTRF assay

Bioorg Med Chem Lett 21: 1844-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.039
BindingDB Entry DOI: 10.7270/Q20G3KFF
More data for this
Ligand-Target Pair