BDBM50338876 CHEMBL1684799::N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-2-methylbenzamide

SMILES: COc1ccc(Cn2ncc(NC(=O)c3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3C)c2N)cc1

InChI Key: InChIKey=QZHXXGQXMOSPCQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50338876   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50338876 (CHEMBL1684799 | N-(5-Amino-1-(4-methoxybenzyl)-1H-...) Show SMILES COc1ccc(Cn2ncc(NC(=O)c3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3C)c2N)cc1 Show InChI InChI=1S/C27H24ClF3N6O3/c1-15-11-17(34-26(39)35-18-6-10-22(28)21(12-18)27(29,30)31)5-9-20(15)25(38)36-23-13-33-37(24(23)32)14-16-3-7-19(40-2)8-4-16/h3-13H,14,32H2,1-2H3,(H,36,38)(H2,34,35,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of C-Raf assessed as [33P]gamma-ATP incorporation into substrate after 40 mins by scintillation counting				Bioorg Med Chem 19: 1915-23 (2011) Article DOI: 10.1016/j.bmc.2011.01.067 BindingDB Entry DOI: 10.7270/Q2D79CD3
					More data for this Ligand-Target Pair