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SMILES: COC(=O)c1ccccc1N1CCN(CC1)C(=O)COCc1ccccc1

InChI Key: InChIKey=AXXDRLJMHXYFJW-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339069   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50339069
PNG
(CHEMBL1688373 | methyl 2-(4-(2-(benzyloxy)acetyl)p...)
Show SMILES COC(=O)c1ccccc1N1CCN(CC1)C(=O)COCc1ccccc1
Show InChI InChI=1S/C21H24N2O4/c1-26-21(25)18-9-5-6-10-19(18)22-11-13-23(14-12-22)20(24)16-27-15-17-7-3-2-4-8-17/h2-10H,11-16H2,1H3
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PC cid
PC sid
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Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Positive allosteric modulation at rat mGluR5 receptor expressed in HEK293 cells assessed as glutamate-induced calcium fluorescence by Fluo-4/AM dye-b...

ACS Med Chem Lett 1: 433-438 (2010)


Article DOI: 10.1021/ml100181a
BindingDB Entry DOI: 10.7270/Q2DJ5FX7
More data for this
Ligand-Target Pair