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BDBM50339338 4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-yl)carbonyl]amino}-1-ethylpropyl)benzyl Acetate::CHEMBL1688090

SMILES: CCC(CC)(NC(=O)c1cnn2c1NC(CC2(C)C)c1ccccc1)c1ccc(COC(C)=O)cc1

InChI Key: InChIKey=VWWPCIMVRXMNJC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339338   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium-sensing receptor (CaSR)


(Homo sapiens (Human))		BDBM50339338
PNG
(4-(1-{[(7,7-Dimethyl-5-phenyl-4,5,6,7-tetrahydropy...)
Show SMILES CCC(CC)(NC(=O)c1cnn2c1NC(CC2(C)C)c1ccccc1)c1ccc(COC(C)=O)cc1
Show InChI InChI=1S/C29H36N4O3/c1-6-29(7-2,23-15-13-21(14-16-23)19-36-20(3)34)32-27(35)24-18-30-33-26(24)31-25(17-28(33,4)5)22-11-9-8-10-12-22/h8-16,18,25,31H,6-7,17,19H2,1-5H3,(H,32,35)
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Article
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of CaSR expressed in CHO cells incubated with compound for 10 mins measured after 1 hr by [35S]GTPgammaS binding assay

J Med Chem 54: 1430-40 (2011)


Article DOI: 10.1021/jm101452x
BindingDB Entry DOI: 10.7270/Q2K35TZ9
More data for this
Ligand-Target Pair