BDBM50339429 3-(4-Chlorophenyl)-3-hydroxy-2-(pyridin-3-ylmethyl)isoindolin-1-one::CHEMBL1688164

SMILES: OC1(N(Cc2cccnc2)C(=O)c2ccccc12)c1ccc(Cl)cc1

InChI Key: InChIKey=DTMGUJFFBQAVJX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50339429   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50339429 (3-(4-Chlorophenyl)-3-hydroxy-2-(pyridin-3-ylmethyl...) Show SMILES OC1(N(Cc2cccnc2)C(=O)c2ccccc12)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H15ClN2O2/c21-16-9-7-15(8-10-16)20(25)18-6-2-1-5-17(18)19(24)23(20)13-14-4-3-11-22-12-14/h1-12,25H,13H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Mdm2 -p53 protein interaction by ELISA				J Med Chem 54: 1233-43 (2011) Article DOI: 10.1021/jm1011929 BindingDB Entry DOI: 10.7270/Q29K4BHN
					More data for this Ligand-Target Pair