BDBM50339489 3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}propanoic Acid::CHEMBL1688486

SMILES: Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1

InChI Key: InChIKey=ADLYBSSJKFIGDM-UHFFFAOYSA-N

Data: 2 KI  5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50339489   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Free fatty acid receptor 1 (Rattus norvegicus)	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO ...				J Med Chem 55: 3756-76 (2012) Article DOI: 10.1021/jm2016123 BindingDB Entry DOI: 10.7270/Q2N58NDH
					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CH...				J Med Chem 55: 3756-76 (2012) Article DOI: 10.1021/jm2016123 BindingDB Entry DOI: 10.7270/Q2N58NDH
					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8.80	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Agonist activity against human GPR40 expressed in CHO cells assessed as increase in intracellular calcium level by FLIPR assay in presence of 0.1% BS...				J Med Chem 54: 1365-78 (2011) Article DOI: 10.1021/jm101405t BindingDB Entry DOI: 10.7270/Q2251JG7
					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay				J Med Chem 60: 2697-2717 (2017) Article DOI: 10.1021/acs.jmedchem.6b01357 BindingDB Entry DOI: 10.7270/Q25141GQ
					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6.70	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells by calcium flux assay				Bioorg Med Chem Lett 24: 2949-53 (2014) Article DOI: 10.1016/j.bmcl.2014.04.065 BindingDB Entry DOI: 10.7270/Q2WD424Z
					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the...				J Med Chem 55: 3756-76 (2012) Article DOI: 10.1021/jm2016123 BindingDB Entry DOI: 10.7270/Q2N58NDH
					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Rattus norvegicus)	BDBM50339489 (3-{4-[(2',6'-Dimethylbiphenyl-3-yl)methoxy]phenyl}...) Show SMILES Cc1cccc(C)c1-c1cccc(COc2ccc(CCC(O)=O)cc2)c1 Show InChI InChI=1S/C24H24O3/c1-17-5-3-6-18(2)24(17)21-8-4-7-20(15-21)16-27-22-12-9-19(10-13-22)11-14-23(25)26/h3-10,12-13,15H,11,14,16H2,1-2H3,(H,25,26)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assay				Bioorg Med Chem Lett 24: 2949-53 (2014) Article DOI: 10.1016/j.bmcl.2014.04.065 BindingDB Entry DOI: 10.7270/Q2WD424Z
					More data for this Ligand-Target Pair