BDBM50340132 CHEMBL1760045::N4-(1H-benzo[d]imidazol-6-yl)-N2-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine

SMILES: COc1cc(Nc2nccc(Nc3ccc4nc[nH]c4c3)n2)cc(OC)c1OC

InChI Key: InChIKey=WTEXDEQWHXZJPA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50340132   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50340132 (CHEMBL1760045 | N4-(1H-benzo[d]imidazol-6-yl)-N2-(...) Show SMILES COc1cc(Nc2nccc(Nc3ccc4nc[nH]c4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C20H20N6O3/c1-27-16-9-13(10-17(28-2)19(16)29-3)25-20-21-7-6-18(26-20)24-12-4-5-14-15(8-12)23-11-22-14/h4-11H,1-3H3,(H,22,23)(H2,21,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human IGF1R				Bioorg Med Chem Lett 21: 2394-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50340132 (CHEMBL1760045 | N4-(1H-benzo[d]imidazol-6-yl)-N2-(...) Show SMILES COc1cc(Nc2nccc(Nc3ccc4nc[nH]c4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C20H20N6O3/c1-27-16-9-13(10-17(28-2)19(16)29-3)25-20-21-7-6-18(26-20)24-12-4-5-14-15(8-12)23-11-22-14/h4-11H,1-3H3,(H,22,23)(H2,21,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of IGF1-induced human IGF1R auto phosphorylation expressed in mouse NIH-3T3 cells preincubated with compound for 1 hr				Bioorg Med Chem Lett 21: 2394-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.075 BindingDB Entry DOI: 10.7270/Q28G8M0D
					More data for this Ligand-Target Pair