BDBM50340503 1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-(trifluoromethylthio)phenyl)imidazolidine-2,4-dione::CHEMBL1762179

SMILES: CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1

InChI Key: InChIKey=SPKNFLLCBPBCIV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50340503   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50340503 (1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...) Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-aventis Curated by ChEMBL					Assay Description Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells after 10 mins by time resolved-fluorescent assay				Bioorg Med Chem Lett 21: 2224-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.003 BindingDB Entry DOI: 10.7270/Q2CC11PK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50340503 (1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...) Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-aventis Curated by ChEMBL					Assay Description Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA				Bioorg Med Chem Lett 21: 2224-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.003 BindingDB Entry DOI: 10.7270/Q2CC11PK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50340503 (1-((2-aminopyridin-4-yl)methyl)-5,5-dimethyl-3-(4-...) Show SMILES CC1(C)N(Cc2ccnc(N)c2)C(=O)N(C1=O)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H17F3N4O2S/c1-17(2)15(26)25(12-3-5-13(6-4-12)28-18(19,20)21)16(27)24(17)10-11-7-8-23-14(22)9-11/h3-9H,10H2,1-2H3,(H2,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-aventis Curated by ChEMBL					Assay Description Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in SF21 cells by time resolved-fluorescent assay				Bioorg Med Chem Lett 21: 2224-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.003 BindingDB Entry DOI: 10.7270/Q2CC11PK
					More data for this Ligand-Target Pair