BindingDB PrimarySearch

BDBM50341035 1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benzo[d]imidazol-2-ylamino)phenyl)-3-methylurea::CHEMBL1760154

SMILES: CNC(=O)Nc1ccc(Nc2nc3ccccc3n2-c2nc(C)nc(N)n2)cc1

InChI Key: InChIKey=LYZVYVLSMGRTPB-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50341035
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of PI3Kalpha				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of PI3Kbeta				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assay				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of 4EBP1 at T37/46				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of mTOR in human U-87 cells assessed as inhibition of phosphorylation of AKT at S473				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50341035 (1-(4-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-b...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma				Bioorg Med Chem Lett 21: 2064-70 (2011) Article DOI: 10.1016/j.bmcl.2011.02.007 BindingDB Entry DOI: 10.7270/Q2FT8MBW
Amgen Inc Curated by ChEMBL					More data for this Ligand-Target Pair