BDBM50341477 8-[5-(2,5-Difluorophenyl)pyridin-3-yl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one::CHEMBL1765223

SMILES: Fc1ccc(F)c(c1)-c1cncc(c1)-c1cc2CCN3c2c(CCC3=O)c1

InChI Key: InChIKey=AEPZBDRKCCYBHK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50341477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 11B2 (CYP11B2) (Homo sapiens (Human))	BDBM50341477 (8-[5-(2,5-Difluorophenyl)pyridin-3-yl]-1,2,5,6-tet...) Show SMILES Fc1ccc(F)c(c1)-c1cncc(c1)-c1cc2CCN3c2c(CCC3=O)c1 Show InChI InChI=1S/C22H16F2N2O/c23-18-2-3-20(24)19(10-18)17-9-16(11-25-12-17)15-7-13-1-4-21(27)26-6-5-14(8-15)22(13)26/h2-3,7-12H,1,4-6H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of human CYP11B2 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assay				J Med Chem 54: 2307-19 (2011) Article DOI: 10.1021/jm101470k BindingDB Entry DOI: 10.7270/Q2765FM6
					More data for this Ligand-Target Pair
Cytochrome P450 11B1, mitochondrial (Homo sapiens (Human))	BDBM50341477 (8-[5-(2,5-Difluorophenyl)pyridin-3-yl]-1,2,5,6-tet...) Show SMILES Fc1ccc(F)c(c1)-c1cncc(c1)-c1cc2CCN3c2c(CCC3=O)c1 Show InChI InChI=1S/C22H16F2N2O/c23-18-2-3-20(24)19(10-18)17-9-16(11-25-12-17)15-7-13-1-4-21(27)26-6-5-14(8-15)22(13)26/h2-3,7-12H,1,4-6H2	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	n/a
Saarland University Curated by ChEMBL					Assay Description Inhibition of human CYP11B1 expressed in hamster V79 MZh cells assessed as conversion of [4-14C]-11-deoxycorticosterone substrate by HPTLC assay				J Med Chem 54: 2307-19 (2011) Article DOI: 10.1021/jm101470k BindingDB Entry DOI: 10.7270/Q2765FM6
					More data for this Ligand-Target Pair