BDBM50341731 3-amino-N-phenyl-6-(m-tolyl)pyrazine-2-carboxamide::CHEMBL1766777

SMILES: Cc1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1

InChI Key: InChIKey=JVLBMTZZNVPFEA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50341731   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA-dependent protein kinase catalytic subunit (Homo sapiens (Human))	BDBM50341731 (3-amino-N-phenyl-6-(m-tolyl)pyrazine-2-carboxamide...) Show SMILES Cc1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H16N4O/c1-12-6-5-7-13(10-12)15-11-20-17(19)16(22-15)18(23)21-14-8-3-2-4-9-14/h2-11H,1H3,(H2,19,20)(H,21,23)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					Assay Description Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay				J Med Chem 54: 2320-30 (2011) Article DOI: 10.1021/jm101488z BindingDB Entry DOI: 10.7270/Q2WS8TK6
					More data for this Ligand-Target Pair
Serine-protein kinase ATM (Homo sapiens (Human))	BDBM50341731 (3-amino-N-phenyl-6-(m-tolyl)pyrazine-2-carboxamide...) Show SMILES Cc1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H16N4O/c1-12-6-5-7-13(10-12)15-11-20-17(19)16(22-15)18(23)21-14-8-3-2-4-9-14/h2-11H,1H3,(H2,19,20)(H,21,23)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					Assay Description Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay				J Med Chem 54: 2320-30 (2011) Article DOI: 10.1021/jm101488z BindingDB Entry DOI: 10.7270/Q2WS8TK6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM50341731 (3-amino-N-phenyl-6-(m-tolyl)pyrazine-2-carboxamide...) Show SMILES Cc1cccc(c1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H16N4O/c1-12-6-5-7-13(10-12)15-11-20-17(19)16(22-15)18(23)21-14-8-3-2-4-9-14/h2-11H,1H3,(H2,19,20)(H,21,23)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					Assay Description Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay				J Med Chem 54: 2320-30 (2011) Article DOI: 10.1021/jm101488z BindingDB Entry DOI: 10.7270/Q2WS8TK6
					More data for this Ligand-Target Pair