BDBM50342586 (E)-3-(2-(3-aminophenyl)-2-oxoethylidene)-4-chloroindolin-2-one::CHEMBL1770524

SMILES: Nc1cccc(c1)C(=O)\C=C1\C(=O)Nc2cccc(Cl)c12

InChI Key: InChIKey=YDHKOLZPXCYPMK-DHZHZOJOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50342586   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-glutamine gamma-glutamyltransferase 2 (TG2) (Homo sapiens (Human))	BDBM50342586 ((E)-3-(2-(3-aminophenyl)-2-oxoethylidene)-4-chloro...) Show SMILES Nc1cccc(c1)C(=O)\C=C1\C(=O)Nc2cccc(Cl)c12 Show InChI InChI=1S/C16H11ClN2O2/c17-12-5-2-6-13-15(12)11(16(21)19-13)8-14(20)9-3-1-4-10(18)7-9/h1-8H,18H2,(H,19,21)/b11-8+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Curated by ChEMBL					Assay Description Inhibition of human transglutaminase 2 using ZGBC as a substrate after 30 to 60 mins by fluorometric assay				Bioorg Med Chem Lett 21: 2692-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.037 BindingDB Entry DOI: 10.7270/Q2CN7471
					More data for this Ligand-Target Pair
Protein-glutamine gamma-glutamyltransferase 2 (TG2) (Homo sapiens (Human))	BDBM50342586 ((E)-3-(2-(3-aminophenyl)-2-oxoethylidene)-4-chloro...) Show SMILES Nc1cccc(c1)C(=O)\C=C1\C(=O)Nc2cccc(Cl)c12 Show InChI InChI=1S/C16H11ClN2O2/c17-12-5-2-6-13-15(12)11(16(21)19-13)8-14(20)9-3-1-4-10(18)7-9/h1-8H,18H2,(H,19,21)/b11-8+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Curated by ChEMBL					Assay Description Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assay				Bioorg Med Chem Lett 21: 2692-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.037 BindingDB Entry DOI: 10.7270/Q2CN7471
					More data for this Ligand-Target Pair