BDBM50342588 (E)-4-chloro-1-isopropyl-3-(2-oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one::CHEMBL1770527

SMILES: CC(C)N1C(=O)\C(=C\C(=O)c2cccnc2)c2c1cccc2Cl

InChI Key: InChIKey=SFZQBIPUYFYIIP-UKTHLTGXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50342588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein-glutamine gamma-glutamyltransferase 2 (TG2) (Homo sapiens (Human))	BDBM50342588 ((E)-4-chloro-1-isopropyl-3-(2-oxo-2-(pyridin-3-yl)...) Show SMILES CC(C)N1C(=O)\C(=C\C(=O)c2cccnc2)c2c1cccc2Cl Show InChI InChI=1S/C18H15ClN2O2/c1-11(2)21-15-7-3-6-14(19)17(15)13(18(21)23)9-16(22)12-5-4-8-20-10-12/h3-11H,1-2H3/b13-9+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Curated by ChEMBL					Assay Description Inhibition of human transglutaminase 2 using ZGBC as a substrate after 30 to 60 mins by fluorometric assay				Bioorg Med Chem Lett 21: 2692-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.037 BindingDB Entry DOI: 10.7270/Q2CN7471
					More data for this Ligand-Target Pair
Protein-glutamine gamma-glutamyltransferase 2 (TG2) (Homo sapiens (Human))	BDBM50342588 ((E)-4-chloro-1-isopropyl-3-(2-oxo-2-(pyridin-3-yl)...) Show SMILES CC(C)N1C(=O)\C(=C\C(=O)c2cccnc2)c2c1cccc2Cl Show InChI InChI=1S/C18H15ClN2O2/c1-11(2)21-15-7-3-6-14(19)17(15)13(18(21)23)9-16(22)12-5-4-8-20-10-12/h3-11H,1-2H3/b13-9+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Stanford University Curated by ChEMBL					Assay Description Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assay				Bioorg Med Chem Lett 21: 2692-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.037 BindingDB Entry DOI: 10.7270/Q2CN7471
					More data for this Ligand-Target Pair