BDBM50343007 (R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine::CHEMBL1770992

SMILES: CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)n1

InChI Key: InChIKey=GCRPPSFRMMXKJN-SNVBAGLBSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343007   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50343007 ((R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...) Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)n1 |r| Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-13-17-11(14)6-12(18-13)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human histamine H4 receptor				Bioorg Med Chem Lett 21: 3113-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.017 BindingDB Entry DOI: 10.7270/Q24X5845
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50343007 ((R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...) Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)n1 |r| Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-13-17-11(14)6-12(18-13)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...				Bioorg Med Chem Lett 21: 3113-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.017 BindingDB Entry DOI: 10.7270/Q24X5845
					More data for this Ligand-Target Pair