Found 3 hits for monomerid = 50343195 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50343195
(CHEMBL1773582 | N-(6-(2-(4-Methyl-N-methylphenylsu...)Show SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C21H19N5O3S2/c1-13-4-7-16(8-5-13)31(28,29)26(3)20-22-11-10-17(24-20)15-6-9-18-19(12-15)30-21(25-18)23-14(2)27/h4-12H,1-3H3,(H,23,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells |
J Med Chem 54: 1789-811 (2011)
Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50343195
(CHEMBL1773582 | N-(6-(2-(4-Methyl-N-methylphenylsu...)Show SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C21H19N5O3S2/c1-13-4-7-16(8-5-13)31(28,29)26(3)20-22-11-10-17(24-20)15-6-9-18-19(12-15)30-21(25-18)23-14(2)27/h4-12H,1-3H3,(H,23,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 269 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay |
J Med Chem 54: 1789-811 (2011)
Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50343195
(CHEMBL1773582 | N-(6-(2-(4-Methyl-N-methylphenylsu...)Show SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1 Show InChI InChI=1S/C21H19N5O3S2/c1-13-4-7-16(8-5-13)31(28,29)26(3)20-22-11-10-17(24-20)15-6-9-18-19(12-15)30-21(25-18)23-14(2)27/h4-12H,1-3H3,(H,23,25,27) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs |
J Med Chem 54: 1789-811 (2011)
Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K |
More data for this Ligand-Target Pair | |