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BDBM50343195 CHEMBL1773582::N-(6-(2-(4-Methyl-N-methylphenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES: CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1

InChI Key: InChIKey=CJVXPWZJWZDNTG-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343195   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50343195
PNG
(CHEMBL1773582 | N-(6-(2-(4-Methyl-N-methylphenylsu...)
Show SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C21H19N5O3S2/c1-13-4-7-16(8-5-13)31(28,29)26(3)20-22-11-10-17(24-20)15-6-9-18-19(12-15)30-21(25-18)23-14(2)27/h4-12H,1-3H3,(H,23,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
38n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha expressed in Sf9 cells


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50343195
PNG
(CHEMBL1773582 | N-(6-(2-(4-Methyl-N-methylphenylsu...)
Show SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C21H19N5O3S2/c1-13-4-7-16(8-5-13)31(28,29)26(3)20-22-11-10-17(24-20)15-6-9-18-19(12-15)30-21(25-18)23-14(2)27/h4-12H,1-3H3,(H,23,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 269n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50343195
PNG
(CHEMBL1773582 | N-(6-(2-(4-Methyl-N-methylphenylsu...)
Show SMILES CN(c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C21H19N5O3S2/c1-13-4-7-16(8-5-13)31(28,29)26(3)20-22-11-10-17(24-20)15-6-9-18-19(12-15)30-21(25-18)23-14(2)27/h4-12H,1-3H3,(H,23,25,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 334n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs


J Med Chem 54: 1789-811 (2011)


Article DOI: 10.1021/jm1014605
BindingDB Entry DOI: 10.7270/Q2TH8N1K
More data for this
Ligand-Target Pair