BDBM50343232 CHEMBL1773559::N-(6-(2-(4-Methoxyphenylthio)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES: COc1ccc(Sc2nccc(n2)-c2ccc3nc(NC(C)=O)sc3c2)cc1

InChI Key: InChIKey=CYLXABNZYVTFFR-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50343232   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50343232 (CHEMBL1773559 | N-(6-(2-(4-Methoxyphenylthio)pyrim...) Show SMILES COc1ccc(Sc2nccc(n2)-c2ccc3nc(NC(C)=O)sc3c2)cc1 Show InChI InChI=1S/C20H16N4O2S2/c1-12(25)22-20-24-17-8-3-13(11-18(17)28-20)16-9-10-21-19(23-16)27-15-6-4-14(26-2)5-7-15/h3-11H,1-2H3,(H,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50343232 (CHEMBL1773559 | N-(6-(2-(4-Methoxyphenylthio)pyrim...) Show SMILES COc1ccc(Sc2nccc(n2)-c2ccc3nc(NC(C)=O)sc3c2)cc1 Show InChI InChI=1S/C20H16N4O2S2/c1-12(25)22-20-24-17-8-3-13(11-18(17)28-20)16-9-10-21-19(23-16)27-15-6-4-14(26-2)5-7-15/h3-11H,1-2H3,(H,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair