BDBM50343249 CHEMBL1773575::N-(6-(2-(4-Methoxy-N-methylphenylsulfonamido)pyrimidin-4-yl)benzo[d]thiazol-2-yl)acetamide

SMILES: COc1ccc(cc1)S(=O)(=O)N(C)c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1

InChI Key: InChIKey=AIBUAENDRJZVDK-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343249   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50343249 (CHEMBL1773575 | N-(6-(2-(4-Methoxy-N-methylphenyls...) Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1 Show InChI InChI=1S/C21H19N5O4S2/c1-13(27)23-21-25-18-9-4-14(12-19(18)31-21)17-10-11-22-20(24-17)26(2)32(28,29)16-7-5-15(30-3)6-8-16/h4-12H,1-3H3,(H,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	76	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of human PI3Kalpha expressed in Sf9 cells				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50343249 (CHEMBL1773575 | N-(6-(2-(4-Methoxy-N-methylphenyls...) Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1 Show InChI InChI=1S/C21H19N5O4S2/c1-13(27)23-21-25-18-9-4-14(12-19(18)31-21)17-10-11-22-20(24-17)26(2)32(28,29)16-7-5-15(30-3)6-8-16/h4-12H,1-3H3,(H,23,25,27)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	336	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of AKT phosphorylation at S473 in human U-87MG cells at 5 mM after 2 hrs				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50343249 (CHEMBL1773575 | N-(6-(2-(4-Methoxy-N-methylphenyls...) Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)c1nccc(n1)-c1ccc2nc(NC(C)=O)sc2c1 Show InChI InChI=1S/C21H19N5O4S2/c1-13(27)23-21-25-18-9-4-14(12-19(18)31-21)17-10-11-22-20(24-17)26(2)32(28,29)16-7-5-15(30-3)6-8-16/h4-12H,1-3H3,(H,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	285	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay				J Med Chem 54: 1789-811 (2011) Article DOI: 10.1021/jm1014605 BindingDB Entry DOI: 10.7270/Q2TH8N1K
					More data for this Ligand-Target Pair