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SMILES: Cn1c(CN2CCC(C(O)C2)c2ccc(cc2)C(F)(F)F)nc2ncccc12

InChI Key: InChIKey=GGANYXPSWRBDMF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50343315   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50343315
PNG
(CHEMBL1774223 | trans-1-((1-Methyl-1H-imidazo[4,5-...)
Show SMILES Cn1c(CN2CCC(C(O)C2)c2ccc(cc2)C(F)(F)F)nc2ncccc12
Show InChI InChI=1S/C20H21F3N4O/c1-26-16-3-2-9-24-19(16)25-18(26)12-27-10-8-15(17(28)11-27)13-4-6-14(7-5-13)20(21,22)23/h2-7,9,15,17,28H,8,10-12H2,1H3
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Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...

J Med Chem 54: 1724-39 (2011)


Article DOI: 10.1021/jm101414h
BindingDB Entry DOI: 10.7270/Q2222V3C
More data for this
Ligand-Target Pair