BDBM50343323 CHEMBL1774231::cis-2-(((3R,4R)-4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpiperidin-1-yl)methyl)-1-methyl-1H-imidazo[4,5-b]pyridine

SMILES: COc1cc(ccc1[C@@H]1CCN(Cc2nc3ncccc3n2C)C[C@@H]1C)C(F)(F)F

InChI Key: InChIKey=XTGROMAGIGWBCC-GOEBONIOSA-N

Data: 1 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50343323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50343323 (CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...) Show SMILES COc1cc(ccc1[C@@H]1CCN(Cc2nc3ncccc3n2C)C[C@@H]1C)C(F)(F)F |r| Show InChI InChI=1S/C22H25F3N4O/c1-14-12-29(13-20-27-21-18(28(20)2)5-4-9-26-21)10-8-16(14)17-7-6-15(22(23,24)25)11-19(17)30-3/h4-7,9,11,14,16H,8,10,12-13H2,1-3H3/t14-,16+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.26E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation counting				J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50343323 (CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...) Show SMILES COc1cc(ccc1[C@@H]1CCN(Cc2nc3ncccc3n2C)C[C@@H]1C)C(F)(F)F |r| Show InChI InChI=1S/C22H25F3N4O/c1-14-12-29(13-20-27-21-18(28(20)2)5-4-9-26-21)10-8-16(14)17-7-6-15(22(23,24)25)11-19(17)30-3/h4-7,9,11,14,16H,8,10,12-13H2,1-3H3/t14-,16+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	76	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced i...				J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50343323 (CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...) Show SMILES COc1cc(ccc1[C@@H]1CCN(Cc2nc3ncccc3n2C)C[C@@H]1C)C(F)(F)F |r| Show InChI InChI=1S/C22H25F3N4O/c1-14-12-29(13-20-27-21-18(28(20)2)5-4-9-26-21)10-8-16(14)17-7-6-15(22(23,24)25)11-19(17)30-3/h4-7,9,11,14,16H,8,10,12-13H2,1-3H3/t14-,16+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	22	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...				J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C
					More data for this Ligand-Target Pair