BDBM50343673 4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-ylamino)piperidine-1-sulfonamide::CHEMBL1773329

SMILES: NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1

InChI Key: InChIKey=OMXIAXJGEYOQEC-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50343673   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of IKK1				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of IKK2 using 5-FAM-GRHDSGLDSMK-NH2 as substrate by TR-FRET assay				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of JNK2				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of JNK1				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of p38alpha				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11 (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of p38beta				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50343673 (4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-yla...) Show SMILES NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 Show InChI InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
Korea Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of JNK3				Bioorg Med Chem Lett 21: 3002-6 (2011) Article DOI: 10.1016/j.bmcl.2011.03.044 BindingDB Entry DOI: 10.7270/Q22V2GDS
					More data for this Ligand-Target Pair